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- Title
Access to Imidazo[1,2- a]imidazolin-2-ones and Functionalization through Suzuki-Miyaura Cross-Coupling Reactions.
- Authors
Grosse, Sandrine; Pillard, Christelle; Himbert, Franck; Massip, Stéphane; Léger, Jean Michel; Jarry, Christian; Bernard, Philippe; Guillaumet, Gérald
- Abstract
We report herein a synthetic pathway to new 6(5)-bromo-5(6)-methylimidazo[1,2- a]imidazolin-2-ones. The synthetic potential of these scaffolds was demonstrated by displacing bromine by Suzuki-Miyaura cross-coupling reactions. A large panel of boronic acids (aryl, heteroaryl or vinyl) could easily be introduced, giving access to a large and diversified library of 6(5)-substituted 5(6)-methylimidazo[1,2- a]imidazolin-2-ones.
- Subjects
IMIDAZOLES; TISSUE scaffolds; COUPLING reactions (Chemistry); BORONIC acids; METHYLPHENIDATE
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 19, p4146
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300268