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- Title
Epicolactone - Natural Product Isolated from the Sugarcane Endophytic Fungus Epicoccum nigrum.
- Authors
da Silva Araújo, Francisca Diana; de Lima Fávaro, Léia Cecilia; Araújo, Welington Luiz; de Oliveira, Fábio Lazzarotto; Aparicio, Ricardo; Marsaioli, Anita Jocelyne
- Abstract
The endophytic fungus Epicoccum nigrum was isolated from sugarcane and the bioguided fractionation of the ethyl acetate extract led to the isolation of epicolactone, mellein, and 4,5-dimethylresorcinol. Characterization of epicolactone by MS, NMR and X-ray crystallography revealed a new natural product with an unusual carbon skeleton. The production of this secondary metabolite decreased in mutants of Epicoccum nigrum transformed by Agrobacterium tumefaciens. Additionally, these mutants produced 4-hydroxymellein.
- Publication
European Journal of Organic Chemistry, 2012, Vol 2012, Issue 27, p5225
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201200757