We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis.
- Authors
Ando, Kunie; Houben, Sarah; Homa, Mégane; de Fisenne, Marie-Ange; Potier, Marie-Claude; Erneux, Christophe; Brion, Jean-Pierre; Leroy, Karelle
- Abstract
Keywords: Alzheimer's disease; endocytosis; genome-wide association study; phosphoinositides; tau; amyloid ß EN Alzheimer's disease endocytosis genome-wide association study phosphoinositides tau amyloid ß N.PAG N.PAG 6 02/04/21 20210122 NES 210122 Introduction Alzheimer's disease (AD) is the most common form of dementia. The brain propagation of tau pathology in AD follows neuroanatomical pathways and can reflect transmission of abnormal tau proteins from cell to cell in a "prion-like" manner. Amyloid-beta plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.
- Subjects
APOLIPOPROTEIN E4; PATHOLOGY; ALZHEIMER'S disease; PROGRESSIVE supranuclear palsy; ENDOCYTOSIS; TAU proteins; CAPPING proteins
- Publication
Frontiers in Molecular Neuroscience, 2021, Vol 13, pN.PAG
- ISSN
1662-5099
- Publication type
Article
- DOI
10.3389/fnmol.2020.583755