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- Title
Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality.
- Authors
van der Heijden M; Pickkers P; van Nieuw Amerongen GP; van Hinsbergh VW; Bouw MP; van der Hoeven JG; Groeneveld AB; van der Heijden, Melanie; Pickkers, Peter; van Nieuw Amerongen, Geerten P; van Hinsbergh, Victor W M; Bouw, Martijn P W J M; van der Hoeven, Johannes G; Groeneveld, A B Johan
- Abstract
<bold>Purpose: </bold>To investigate whether angiopoietin-2, von Willebrand factor (VWF) and angiopoietin-1 relate to surrogate indicators of vascular permeability, pulmonary dysfunction and intensive care unit (ICU) mortality throughout the course of septic shock.<bold>Methods: </bold>In 50 consecutive mechanically ventilated septic shock patients, plasma angiopoietin-2, VWF and angiopoietin-1 levels and fluid balance, partial pressure of oxygen/inspiratory oxygen fraction and the oxygenation index as indicators of vascular permeability and pulmonary dysfunction, respectively, were measured until day 28.<bold>Results: </bold>Angiopoietin-2 positively related to the fluid balance and pulmonary dysfunction, was higher in non-survivors than in survivors and independently predicted non-survival throughout the course of septic shock. VWF inversely related to the fluid balance and pulmonary dysfunction throughout the course of septic shock, was comparable between survivors and non-survivors and predicted non-survival on day 0 only. Angiopoietin-1 positively related to pulmonary dysfunction throughout the course, but did not differ between survivors and non-survivors.<bold>Conclusions: </bold>In contrast to VWF, plasma angiopoietin-2 positively relates to fluid balance, pulmonary dysfunction and mortality throughout the course of septic shock, in line with a suggested mediator role of the protein.
- Publication
Intensive Care Medicine, 2009, Vol 35, Issue 9, p1567
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-009-1560-y