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- Title
Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis.
- Authors
O'Connor, Lucy; Anh, Duong Van; Chau, Tran Thi Hong; Chau, Nguyen Van Vinh; Huong, Lan Nguyen Phu; Wolbers, Marcel; Day, Jeremy N
- Abstract
We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.
- Subjects
PREDICTIVE tests; AMPHOTERICIN B; HETEROCYCLIC compounds; CRYPTOCOCCUS; CRYPTOCOCCUS neoformans; DISEASE susceptibility; SURVIVAL analysis (Biometry); MENINGITIS; FLUCONAZOLE; STATISTICAL correlation; DRUG resistance in microorganisms; AIDS; DISEASE complications
- Publication
Clinical Infectious Diseases, 2021, Vol 73, Issue 7, pe2338
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciaa1544