We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
TAK1 Regulates Cartilage and Joint Development via the MAPK and BMP Signaling Pathways.
- Authors
Gunnell, Lea M.; Jonason, Jennifer H.; Loiselle, Alayna E.; Kohn, Anat; Schwarz, Edward M.; Hilton, Matthew J.; O'Keefe, Regis J.
- Abstract
The article discusses a study on the role of canonical transforming growth factor β (TGF-&beta) activated kinase (TAK1) in regulating cartilage and joint development through the mitogen-activated protein kinase (MAPK) and bone morphogenetic protein (BMP) signaling pathways. It explains apoptosis and chondrocyte proliferation. The results of the study found that the loss of TAK1 causes impaired activation of the downstream MAPK target p38 and reduced activation of the BMP/SMAD signaling pathway.
- Subjects
TRANSFORMING growth factors-beta; MITOGEN-activated protein kinases; CARTILAGE; JOINTS (Anatomy); APOPTOSIS; CARTILAGE cells; CELL proliferation
- Publication
Journal of Bone & Mineral Research, 2010, Vol 25, Issue 8, p1784
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.79