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- Title
Biomarkers of angiogenesis in twin gestations and the risk of preeclampsia--review of the current literature.
- Authors
Kozlowski, Szymon; Zgliczynska, Magdalena; Kosinska-Kaczynska, Katarzyna
- Abstract
Twin pregnancy is one of the key risk factors for the development of preeclampsia. Soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin are molecules involved in the process of angiogenesis with a proven role in the pathogenesis of preeclampsia. The aim of the review was to summarize available data on maternal serum levels of the biomarkers of angiogenesis and their usefulness in predicting preeclampsia in twin pregnancies. Most of available data suggest biomarkers concentrations differ between singleton and twin gestation and are related to chorionicity of twin pregnancy. Several algorithms including biomarkers of angiogenesis in prediction of PE in twin pregnancy are available and seem promising, however more large prospective surveys are necessary to assess their usefulness in general clinic use.
- Subjects
TWINS; NEOVASCULARIZATION; GESTATIONAL age; PREECLAMPSIA; ENDOGLIN
- Publication
Ginekologia Polska, 2020, Vol 91, Issue 12, p773
- ISSN
0017-0011
- Publication type
Article
- DOI
10.5603/GP.a2020.0133