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- Title
Stage-Specific Functions of the Small Rho GTPases Cdc42 and Racl for Adult Hippocampal Neurogenesis.
- Authors
Vadodaria, Krishna C.; Brakebusch, Cord; Suter, Ueli; Jessberger, Sebastian
- Abstract
The molecular mechanisms underlying the generation, maturation, and integration of new granule cells generated throughout life in the mammalian hippocampus remain poorly understood. Small Rho GTPases, such as Cdc42 and Racl, have been implicated previously in neural stem/progenitor cell (NSPC) proliferation and neuronal maturation during embryonic development. Here we used conditional genetic deletion and virus-based loss-of-function approaches to identify temporally distinct functions for Cdc42 and Racl in adult hippocampal neurogenesis. We found that Cdc42 is involved in mouse NSPC proliferation, initial dendritic development, and dendritic spine maturation. In contrast, Racl is dispensable for early steps of neuronal development but is important for late steps of dendritic growth and spine maturation. These results establish cell-autonomous and stage-specific functions for the small Rho GTPases Cdc42 and Racl in the course of adult hippocampal neurogenesis.
- Subjects
GUANOSINE triphosphatase; HIPPOCAMPUS (Brain); DEVELOPMENTAL neurobiology; MOLECULAR biology; NEURAL stem cells; PROGENITOR cells; CELL proliferation
- Publication
Journal of Neuroscience, 2013, Vol 33, Issue 3, p1179
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2103-12.2013