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- Title
Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats.
- Authors
Xin-Hong Zhu; Yan, Hua-Cheng; Jie Zhang; Hong-Da Qu; Xing-Sheng Qiu; Liang Chen; Shu-Ji Li; Xiong Cao; Bean, Jonathan C.; Long-Hua Chen; Xi-He Qin; Ji-Hong Liu; Xiao-Chun Bai; Lin Mei; Tian-Ming Gao
- Abstract
Increasing evidence indicates that stimulating hippocampal neurogenesis could provide novel avenues for the treatment of depression, and recent studies have shown that in vitro neurogenesis is enhanced by hypoxia. The aim of this study was to investigate the potential regulatory capacity of an intermittent hypobaric hypoxia (IH) regimen on hippocampal neurogenesis and its possible antidepressant-like effect. Here, we show that IH promotes the proliferation ofendogenous neuroprogenitors leading to more newborn neurons in hippocampus in adult rats. Importantly, IH produces antidepressant-like effects in multiple animal models screening for antidepressant activity, including the forced swimming test, chronic mild stress paradigm, and novelty-suppressed feeding test. Hippocampal x-ray irradiation blocked both the neurogenic and behavioral effects of IH, indicating that IH likely produces antidepressant-like effects via promoting neurogenesis in adult hippocampus. Furthermore, IH stably enhanced the expression of BDNF in hippocampus; both the antidepressantlike effect and~ the enhancement of cell proliferation induced by IH were totally blocked by pharmacological and biological inhibition of BDNF-TrkB (tyrosine receptor kinase B) signaling, suggesting that the neurogenic and antidepressant-like effects of IH may involve BDNF signaling. These observations might contribute to both a better understanding of physiological responses to IH and to developing IH as a novel therapeutic approach for depression.
- Subjects
HYPOXEMIA; DEVELOPMENTAL neurobiology; ANTIDEPRESSANTS; DENTATE gyrus; MENTAL depression; CELL proliferation; LABORATORY rats
- Publication
Journal of Neuroscience, 2010, Vol 30, Issue 38, p12653
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.6414-09.2010