We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Human Basal Ganglia Modulate Frontal-Posterior Connectivity during Attention Shifting.
- Authors
van Schouwenburg, Martine R.; den Ouden, Hanneke E. M.; Cools, Roshan
- Abstract
Current models of flexible cognitive control emphasize the role of the prefrontal cortex. This region has been shown to control attention by biasing information processing in favor of task-relevant representations. However, the prefrontal cortex does not act in isolation. We used functional magnetic resonance imaging combined with nonlinear dynamic causal modeling to demonstrate that the basal ganglia play a role in modulating the top-down influence of the prefrontal cortex on visual processing in humans. Specifically, our results reveal that connectivity between the prefrontal cortex and stimulus-specific visual association areas depends on activity in the ventral striatopallidum, elicited by salient events leading to shifts in attention. These data integrate disparate literatures on top-down control by the prefrontal cortex and selective gating by the basal ganglia and highlight the importance of the basal ganglia for high-level cognitive control.
- Subjects
VISION; ATTENTION; BASAL ganglia; MAGNETIC resonance imaging; BRAIN stimulation; PREFRONTAL cortex
- Publication
Journal of Neuroscience, 2010, Vol 30, Issue 29, p9910
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1111-10.2010