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- Title
Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus.
- Authors
Weg, Cornelia A M van de; Thomazella, Mateus V; Marmorato, Mariana P; Correia, Carolina A; Dias, Juliana Z C; Maestri, Alvino; Zanella, Luiz G F A B E; Cerqueira, Natalia B; Félix, Alvina C; Moreira, Carlos H V; Buccheri, Renata; Costa, Priscilla R; Kallás, Esper G
- Abstract
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.
- Subjects
YELLOW fever; DISSEMINATED intravascular coagulation; DEATH rate; PHYTOPLASMAS; ENDOTHELIAL cells
- Publication
Journal of Infectious Diseases, 2024, Vol 230, Issue 1, pe60
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad389