We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Seroepidemiological Reconstruction of Long-term Chikungunya Virus Circulation in Burkina Faso and Gabon.
- Authors
Lim, Jacqueline Kyungah; Ridde, Valery; Agnandji, Selidji Todagbe; Lell, Bertrand; Yaro, Seydou; Yang, Jae Seung; Hoinard, Damien; Weaver, Scott C; Vanhomwegen, Jessica; Salje, Henrik; Yoon, In-Kyu
- Abstract
Chikungunya virus (CHIKV) is a major public health concern worldwide. However, infection levels are rarely known, especially in Africa. We recruited individuals from Ouagadougou, Burkina Faso and Lambaréné, Gabon (age range, 1–55 years), tested their blood for CHIKV antibodies, and used serocatalytic models to reconstruct epidemiological histories. In Ouagadougou, 291 of 999 (29.1%) individuals were seropositive, ranging from 2% among those aged <10 years to 66% in those aged 40–55 years. We estimated there were 7 outbreaks since the 1970s but none since 2001, resulting in 600 000 infections in the city, none of which were reported. However, we could not definitively conclude whether infections were due to CHIKV or o'nyong-nyong, another alphavirus. In Lambaréné, 117 of 427 (27%) participants were seropositive. Our model identified a single outbreak sometime since 2007, consistent with the only reported CHIKV outbreak in the country. These findings suggest sporadic outbreaks in these settings and that the burden remains undetected or incorrectly attributed.
- Subjects
BURKINA Faso; OUAGADOUGOU (Burkina Faso); CHIKUNGUNYA virus; PUBLIC health
- Publication
Journal of Infectious Diseases, 2023, Vol 227, Issue 2, p261
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiac246