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- Title
Intranasal antihistamine and corticosteroid to treat allergic rhinitis: A systematic review and meta‐analysis.
- Authors
Kim, Minji; Ryu, Gwanghui; Kang, Sung‐Yoon; Kim, Mi‐Ae; Yang, Song‐I; Lee, Il Hwan; Choi, Gil‐Soon; Kim, Hyun‐Jung; Lee, Sang Min; Kim, Dong‐Kyu; Choi, Jeong Hee; Yang, Hyeon‐Jong; Kim, Soo Whan
- Abstract
Compared to INCS monotherapy, INCS/INAH combination therapy reduced the mean morning and evening 12-h reflective total nasal symptom score (TNSS) more significantly (MD -0.44, 95% CI -0.61 to -0.27, I P i < 0.00001, I I i SP 2 sp = 8%),as well as the total ocular symptom score (MD -0.62, 95% CI -1.05 to -0.19, I P i = 0.005, I I i SP 2 sp = 36%), but not the total symptom score (MD -0.66, 95% CI -2.02 to 0.71, I P i = 0.34, I I i SP 2 sp = 98%). GLO:1X5/01nov22:all15415-fig-0001.jpg PHOTO (COLOR): 1 Comparison of changes in symptom scores after treatment between INCS/INAH combination therapy and INCS monotherapy. Recently, combination therapy with intranasal corticosteroid (INCS) and intranasal antihistamine (INAH) has been recommended as an alternative to INCS monotherapy for patients with allergic rhinitis;1 however, only one meta-analysis compared treatment outcomes between fluticasone/azelastine combination therapy and fluticasone monotherapy, groups; other INCS/INAH combination therapies and INCS monotherapies were not evaluated.2 The PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and MEDLINE databases were systematically searched for both randomized controlled trials (RCTs) and non-RCTs, in accordance with the recommendations of the Cochrane handbook.3 In total, 19,685 studies were initially identified and retrieved, of which 19,643 were excluded after title and abstract screening.
- Subjects
ALLERGIC rhinitis; ANTIHISTAMINES; CORTICOSTEROIDS
- Publication
Allergy, 2022, Vol 77, Issue 11, p3436
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15415