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- Title
Study of a combined percutaneous local anaesthetic and the TDS<sup>®</sup> system for venepuncture.
- Authors
Tucker, A. T.; Chik, Z.; Michaels, L.; Kirby, K.; Seed, M. P.; Johnston, A.; Alam, C. A. S.
- Abstract
Transdermal Delivery System (TDS®) is a liquid formulation which can be applied to the skin via a metered pump spray to deliver drug across skin. This placebo controlled, double blind trial compared anaesthetic properties of two TDS® systems (TDS®α and TDS®β) with placebo. The active and placebo treatments were applied to the dorsum of the hands, bilaterally and simultaneously for 5 min on 100 healthy volunteers. Following cannulation, pain perception was measured using the verbal rating score (VRS) and visual analogue score (VAS). Lidocaine plasma levels were assessed at 0 and 2 h. The VRS and VAS results show that TDS®β significantly decreased pain score compared to placebo (p < 0.02). Blood lidocaine at 2 h post application was also higher for TDS®β than for TDS®α, suggesting that a 5 min application of TDS®β was effective in delivering local anaesthetic and accelerating the onset of skin anaesthesia prior to venous cannulation in adults.
- Subjects
TRANSDERMAL medication; DRUG administration; DRUG delivery devices; ANESTHETICS; CLINICAL trials; PLACEBOS; BLOOD plasma; LIDOCAINE
- Publication
Anaesthesia, 2006, Vol 61, Issue 2, p123
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1111/j.1365-2044.2005.04432.x