We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Initial phase II clinical studies on midaglizole (DG-5128). A new hypoglycemic agent.
- Authors
Kawazu, S.; Suzuki, M.; Negishi, K.; Ishii, J.; Sando, H.; Katagiri, H.; Kanazawa, Y.; Yamanouchi, S.; Akanuma, Y.; Kajinuma, H.; Suzuki, K.; Watanabe, K.; Itoh, T.; Kobayashi, T.; Kosaka, K.
- Abstract
Midaglizole (DG-5128), 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridine dihydrochloride sesquihydrate, is a new type of oral antidiabetic agent that has an alpha 2-adrenoceptor-antagonizing effect. As previously reported, midaglizole reduces plasma glucose, mainly by stimulation of insulin secretion, and inhibits epinephrine-induced platelet aggregation in normal human subjects. In this study, the clinical safety and efficacy of short-term administration of midaglizole were evaluated in 47 patients with non-insulin-dependent diabetes mellitus (NIDDM). After an observation period on diet or sulfonylurea treatment (1 patient was on insulin), patients received 150-250 mg 3 times a day of midaglizole for 2-4 wk, (some patients continued treatment for greater than 4 wk). In 20 of the patients first treated with diet and then switched to midaglizole treatment, fasting plasma glucose (FPG) decreased significantly from 187 +/- 10 mg/dl (mean +/- SE) to 147 +/- 13 mg/dl (P less than .05) and 120 +/- 6 mg/dl (P less than .01) 2 and 4 wk, respectively, after administration of midaglizole. Glycosylated hemoglobin (HbA1) also decreased from 12.0 +/- 0.7 to 11.3 +/- 1.1 and 10.7 +/- 0.6% after 2 and 4 wk, respectively. In 23 of the patients whose treatment was changed from sulfonylureas to midaglizole, FPG, and HbA1 levels were maintained at the same values obtained before administration of midaglizole. In patients treated with midaglizole for greater than 12 wk, FPG and HbA1 were kept at the lowered levels.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects
BLOOD sugar; CLINICAL drug trials; GLUCOSE tolerance tests; HYPOGLYCEMIC agents; IMIDAZOLES; TYPE 2 diabetes; ORAL drug administration; TIME
- Publication
Diabetes, 1987, Vol 36, Issue 2, p221
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.36.2.221