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- Title
Histopathology of SPINK-1 Hereditary Pancreatitis.
- Authors
Felicelli, Christopher; Pezhouh, Maryam K.
- Abstract
Hereditary pancreatitis is a rare form of recurrent acute pancreatitis that typically has an onset in early adulthood. We report a rare case of hereditary pancreatitis in an individual with a serine protease inhibitor Kazal type 1 (SPINK1) mutation. Histologically the pancreas showed features of chronic pancreatitis with variable fibrosis, acinar destruction, and prominent inspissated secretions within the pancreatic ducts. Additionally, focal areas of low-grade pancreatic intraepithelial neoplasia (PanIN) were present. Although the histopathology of common gene mutations resulting in hereditary pancreatitis have been well described, the histopathology of pancreatitis secondary to SPINK1 mutation has been described in only one previous study.
- Subjects
PANCREATIC duct; PANCREATIC intraepithelial neoplasia; PANCREATITIS; CHRONIC pancreatitis; PANCREATIC secretions; PROTEASE inhibitors
- Publication
International Journal of Surgical Pathology, 2021, Vol 29, Issue 5, p529
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/1066896920980086