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- Title
Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy.
- Authors
Chen, Chen-Yu; Wu, Re-Wen; Tsai, Nai-Wen; Lee, Mel S.; Lin, Wei-Che; Hsu, Mei-Chi; Huang, Chih-Cheng; Lai, Yun-Ru; Kung, Chia-Te; Wang, Hung-Chen; Su, Yu-Jih; Su, Chih-Min; Hsiao, Sheng-Yuan; Cheng, Ben-Chung; Chiang, Yi-Fang; Lu, Cheng-Hsien
- Abstract
<bold>Background: </bold>Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesis that hyperbaric oxygen therapy (HBOT) both improves the clinical short-term outcomes and increases the number of circulating EPCs and antioxidant capacity.<bold>Methods: </bold>The numbers of circulating EPCs [CD133+/CD34+ (%), KDR+/CD34+ (%)], biomarkers for oxidative stress (thiols and thiobarbituric acid-reactive substances), and clinical scores (National Institutes of Health Stroke Scale [NIHSS], Barthel index [BI], and modified Rankin Scale [MRS]) were prospectively evaluated in 25 patients with acute non-cardioembolic stroke under HBOT at two time points (pre- and post-HBOT). The biomarkers and clinical scores were compared with those of 25 age- and sex-matched disease controls.<bold>Results: </bold>The numbers of KDR+/CD34+ (%) in the HBOT group following HBOT increased significantly, whereas the numbers of CD133+/CD34+ (%) also showed a tendency to increase without statistical significance. The mean high-sensitivity C-reactive protein levels showed significant decrease post-HBOT follow-up in the HBOT group. The changes in KDR+/CD34+EPC (%) numbers were positively correlated with changes in clinical outcomes scores (BI, NIHSS, and MRS) in the HBOT group.<bold>Conclusions: </bold>Based on the results of our study, HBOT can both improve short-term clinical outcomes and increase the number of circulating EPCs in patients with acute non-cardioembolic stroke.
- Subjects
PROGENITOR cells; HYPERBARIC oxygenation; C-reactive protein; CAUSES of death; ENDOTHELIAL cells; OXIDANT status
- Publication
Journal of Translational Medicine, 2018, Vol 16, Issue 1, pN.PAG
- ISSN
1479-5876
- Publication type
journal article
- DOI
10.1186/s12967-018-1629-x