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- Title
Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution.
- Authors
Weinmayr, Gudrun; Hennig, Frauke; Fuks, Kateryna; Nonnemacher, Michael; Jakobs, Hermann; Möhlenkamp, Stefan; Erbel, Raimund; Jöckel, Karl-Heinz; Hoffmann, Barbara; Moebus, Susanne; Heinz Nixdorf Recall Investigator Group
- Abstract
<bold>Background: </bold>Studies investigating the link between long-term exposure to air pollution and incidence of diabetes are still scarce and results are inconsistent, possibly due to different compositions of the particle mixture. We investigate the long-term effect of traffic-specific and total particulate matter (PM) and road proximity on cumulative incidence of diabetes mellitus (mainly type 2) in a large German cohort.<bold>Methods: </bold>We followed prospectively 3607 individuals without diabetes at baseline (2000-2003) from the Heinz Nixdorf Recall Study in Germany (mean follow-up time 5.1 years). Mean annual exposures to total as well as traffic-specific PM10 and PM2.5 at residence were estimated using a chemistry transport model (EURAD, 1 km(2) resolution). Effect estimates for an increase of 1 μg/m(3) in PM were obtained with Poisson regression adjusting for sex, age, body mass index, lifestyle factors, area-level and individual-level socio-economic status, and city.<bold>Results: </bold>331 incident cases developed. Adjusted RRs for total PM10 and PM2.5 were 1.05 (95%-CI: 1.00;1.10) and 1.03 (95%-CI: 0.95;1.12), respectively. Markedly higher point estimates were found for local traffic-specific PM with RRs of 1.36 (95%-CI: 0.98;1.89) for PM10 and 1.36 (95%-CI: 0.97;1.89) for PM2.5. Individuals living closer than 100 m to a busy road had a more than 30% higher risk (1.37;95%-CI: 1.04;1.81) than those living further than 200 m away.<bold>Conclusions: </bold>Long-term exposure to total PM increases type two diabetes risk in the general population, as does living close to a major road. Local traffic-specific PM was related to higher risks for type two diabetes than total PM.
- Publication
Environmental Health: A Global Access Science Source, 2015, Vol 14, Issue 1, p53
- ISSN
1476-069X
- Publication type
journal article
- DOI
10.1186/s12940-015-0031-x