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- Title
Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report.
- Authors
Hirai, Kuniaki; Homma, Tetsuya; Yamaguchi, Fumihiro; Yamaguchi, Munehiro; Suzuki, Shintaro; Tanaka, Akihiko; Ohnishi, Tsukasa; Sagara, Hironori
- Abstract
<bold>Background: </bold>Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection is a major cause of AE-IPF, no reports have indicated pertussis infection as a cause. Here we report two cases of pertussis infection-induced AE-IPF.<bold>Case Presentation: </bold>Both patients presented with a chief complaint of acute respiratory distress and were previously diagnosed with idiopathic pulmonary fibrosis (IPF). Neither patient had received any pertussis vaccination since adolescence. Both patients were diagnosed with AE-IPF accompanying acute pertussis infection based on chest computed tomography and serum pertussis toxin antibody > 100 EU/mL. Both patients were treated with macrolide antibiotics and systemic corticosteroids. Both patients were able to be discharged and return home.<bold>Conclusions: </bold>The presence of pertussis infection in AE-IPF can present a diagnostic challenge, as coughing accompanying pertussis may be difficult to distinguish from IPF-associated coughing. Pertussis infection should be assayed in AE-IPF patients. Since pertussis can be prevented with vaccination and is expected to be affected by antibiotics, consideration of pertussis infection as a causative virulent factor of AE-IPF may be important for management of subjects with IPF.
- Subjects
DISEASE exacerbation; IDIOPATHIC pulmonary fibrosis; WHOOPING cough; MACROLIDE antibiotics; IDIOPATHIC interstitial pneumonias; OXYGEN therapy
- Publication
BMC Pulmonary Medicine, 2019, Vol 19, Issue 1, pN.PAG
- ISSN
1471-2466
- Publication type
journal article
- DOI
10.1186/s12890-019-0779-9