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- Title
Increased osteopontin protein expression may be correlated with poor prognosis in non-small-cell lung cancer: A meta analysis.
- Authors
Shao-Min Shi; Zhen-Bo Su; Jian-Jun Zhao; Du-Juan Yu; Jun-Wei Tu; Jing Qian Zhu; Jian-Ping Zhao; Lin Sheng; Sai-Bin Wang; Yi-Jun Sheng; Hui-Jun Chen; Jiang-Hua Tian; Yi Zhang; Jing Wang; Shi, Shao-Min; Su, Zhen-Bo; Zhao, Jian-Jun; Yu, Du-Juan; Tu, Jun-Wei; Zhu, Jing Qian
- Abstract
<bold>Aim: </bold>The present meta-nalysis investigates the prognostic value of osteopontin. (OPN) expression in patients with non-small-cell lung cancer. (NSCLC).<bold>Materials and Methods: </bold>The Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013) were searched, without language restrictions, to retrieve studies related to OPN and NSCLC. We compiled carefully selected data and a meta-analysis was conducted using STATA software (Version 12.0, Stata Corporation, and College Station, Texas USA). Hazard ratios (HR) with corresponding 95% confidence interval (95%CI) were calculated.<bold>Results: </bold>Ten clinical cohort studies were selected for statistical analysis, representing a total of 1,133 NSCLC patients. The main findings of our meta-analysis are that patients who were OPN-positive had significantly shorter overall survival than OPN-negative patients. (HR = 1.47, 95%CI = 1.15. ~ 1.79,P< 0.001). Ethnicity.stratified analysis revealed a significant correlation between expression levels of OPN and poor prognosis of NSCLC patients among both Caucasians and Asians. (Asians: HR = 1.53, 95%CI = 0.95. ~ 2.11, P < 0.001; Caucasians: HR = 1.56, 95%CI = 1.08. ~ 2.03, P < 0.001; respectively).<bold>Conclusions: </bold>The present meta-analysis is consistent with the hypothesis that increased expression of OPN protein may be significantly associated with poor prognosis in patients with NSCLC.
- Subjects
META-analysis; OSTEOPONTIN; PROTEIN expression; NON-small-cell lung carcinoma; COHORT analysis; COMPARATIVE studies; GENES; LUNG cancer; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; PROTEINS; RESEARCH; SURVIVAL analysis (Biometry); SYSTEMATIC reviews; PROTEOMICS; EVALUATION research
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 1, p277
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.150362