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- Title
Radiotherapy with temozolomide provides better survival in the newly diagnosed glioblastoma multiforme: A meta-analysis.
- Authors
Chonghao Wang; Na Zhu; Linshu Wang; Zhe An; Wang, Chonghao; Zhu, Na; Wang, Linshu; An, Zhe
- Abstract
<bold>Background: </bold>The optimal treatment for patients with newly diagnosed glioblastoma multiforme (GBM) remains controversial. The purpose of this meta-analysis was to systematically evaluate radiotherapy/temozolomide (TMZ) versus radiotherapy for treating newly diagnosed GBM.<bold>Materials and Methods: </bold>Six electronic databases (PubMed, EMBASE, MEDLINE, Web of Science, Cochrane Library, and CNKI) were searched for relevant publications up to November 05, 2014. RevMan version 5.2 software was used for statistical analysis.<bold>Results: </bold>A total of 9 studies were identified in this analyses, which included 986 patients. The summary risk ratio (RR) for overall survival and the progression-free survival (PFS) was the measure of interest. Results revealed that the addition of TMZ to radiotherapy resulted in a statistically significant survival benefit in poor prognosis patients with newly diagnosed glioblastoma (RR = 2.93 [95% confidence interval (CI) 2.29, 3.75], P < 0.00001). Moreover, radiotherapy plus TMZ was more beneficial than radiotherapy alone in improving PFS (RR = 3.52, [95% CI 2.53, 4.89], P < 0.00001). However, certain grade 3-4 hematological toxicities were significantly more common with TMZ.<bold>Conclusions: </bold>This meta-analysis suggests that radiotherapy/TMZ provides better survival than radiotherapy alone in treating GBM.
- Subjects
ANTINEOPLASTIC agents; COMBINED modality therapy; COMPARATIVE studies; RESEARCH methodology; GLIOMAS; MEDICAL cooperation; META-analysis; RESEARCH; SURVIVAL analysis (Biometry); EVALUATION research; TREATMENT effectiveness; PUBLICATION bias; DACARBAZINE; ODDS ratio; DIAGNOSIS; THERAPEUTICS
- Publication
Journal of Cancer Research & Therapeutics, 2015, Vol 11, pC196
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.168184