We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population.
- Authors
Zhao, Quan-ming; Guo, Xiong; Lai, Jiang-hua; Tan, Wu-hong; Wang, Wei-zhuo; Dang, Xiao-qian
- Abstract
The objective of this study is to investigate the relationship between single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor-α (TNF-α) and Fas genes and Kashin-Beck disease (KBD) in Shaanxi province, Northwest in China. Blood samples of 388 residents were collected from 14 KBD villages in Linyou and Yongshou counties, Shaanxi, Northern of China. One hundred eighty-six cases with KBD and 202 cases of health in KBD areas were diagnosed by 'Diagnosis Criterion of Kashin-Beck disease in China (WS/T207- 2010)'. The TNF-α −308G/A, TNF-α −238G/A, and Fas −670A/G SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism in combination with sequence analysis in KBD and healthy control groups. The genotypes and allele frequencies distribution of these SNPs were then analyzed. TNF-α −308A allele frequency in KBD patients were significantly higher than that in healthy controls. Although TNF-α −238 genotypes and allele frequencies were not significantly different between KBD patients and the healthy controls, GA genotype and A allele frequency in KBD patients were higher than those in healthy controls. The TNF-α −308G/A SNPs were associated with the susceptibility of KBD.
- Subjects
NORTHWEST China; TUMOR necrosis factors; FAS proteins; KASHIN-Beck disease; SINGLE nucleotide polymorphisms; PROMOTERS (Genetics); RESTRICTION fragment length polymorphisms; DISEASE susceptibility
- Publication
Clinical Rheumatology, 2012, Vol 31, Issue 7, p1051
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-012-1975-7