We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Elevated plasma homocysteine: cause or consequence of myocardial infarction?
- Authors
Hultdin, J.; Thøgersen, A. M.; Jansson, J.-H.; Nilsson, T. K.; Weinehall, L.; Hallmans, G.
- Abstract
Hultdin J, Thøgersen AM, Jansson J-H, Nilsson TK, Weinehall L, Hallmans G (Umeå University Hospital, Umeå, Sweden; National University Hospital, Copenhagen, Denmark; Skellefteå County Hospital, University of Umeå, Sweden; andÖrebro University Hospital,Örebro, Sweden). Elevated plasma homocysteine: cause or consequence of myocardial infarction?J Intern Med2004;256:491–498.To determine whether a first myocardial infarction leads to increased plasma homocysteine concentrations and whether the association between homocysteine and myocardial infarction was greater at follow-up compared with baseline.A population-based, prospective, nested case-referent study.Screening took place at the nearest health survey centre in northern Sweden.Of more than 36 000 persons screened, 78 developed a first myocardial infarction (average 18 months after sampling). Fifty of these had participated in a follow-up health survey (average 8½ years between surveys) and were sex- and age-matched with 56 referents.Comparison of plasma homocysteine levels in case and referent subjects before and after development of a first myocardial infarction.No statistically significant difference was found between cases and referents regarding homocysteine at baseline or follow-up. Plasma homocysteine and plasma creatinine increased significantly, and plasma albumin decreased significantly over time. Conditional univariate logistic regression indicated that high homocysteine at follow-up but not baseline was associated with first myocardial infarction (OR 2.49; 95% CI: 1.03–6.02), but the relation disappeared in multivariate analyses including plasma creatinine and plasma albumin. High plasma creatinine remained associated with first myocardial infarction at both baseline (OR 2.94; 95% CI: 1.05–8.21) and follow-up (OR 3.38; 95% CI: 1.21–9.48).In this study, first myocardial infarction did not cause increased plasma homocysteine concentration.
- Subjects
HOMOCYSTEINE; MYOCARDIAL infarction; BLOOD plasma; CREATININE; ALBUMINS; SULFUR amino acids
- Publication
Journal of Internal Medicine, 2004, Vol 256, Issue 6, p491
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1111/j.1365-2796.2004.01415.x