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- Title
Possible Associations between Successful Aging and Polymorphic Markers in the Werner Gene Region.
- Authors
SILD, MARI; KOCA, CEMILE; BENDIXEN, METTE H.; FREDERIKSEN, HENRIK; McGUE, MATT; KØLVRAA, STEEN; CHRISTENSEN, KAARE; NEXØ, BJØRN
- Abstract
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner ( WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5′ flanking region and 5′ UTR to be significantly associated with the cognitive functioning level in old age.
- Subjects
WERNER'S syndrome; PROGERIA; COGNITION; AGING; DEVELOPMENTAL biology
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1067, Issue 1, p309
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1354.041