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- Title
Interleukin-10 Gene Promoter Region Polymorphisms in Patients with Type 1 Diabetes and Autoimmune Thyroid Disease.
- Authors
IDE, AKANE; KAWASAKI, EIJI; ABIRU, NORIO; SUN, FUYAN; FUKUSHIMA, TETSUYA; ISHII, REIKO; TAKAHASHI, RYOKO; KUWAHARA, HIRONAGA; FUJITA, NARUHIRO; KITA, ATSUSHI; IMAIZUMI, MISA; OSHIMA, KATSUYA; USA, TOSHIRO; UOTANI, SHIGEO; EJIMA, ERI; YAMASAKI, HIRONORI; ASHIZAWA, KIYOTO; YAMAGUCHI, YOSHIHIKO; EGUCHI, KATSUMI
- Abstract
A bstract: Type 1 diabetes is a heterogeneous autoimmune disease and is frequently associated with other organ-specific autoimmune diseases, including autoimmune thyroid disease (AITD). Type 1 diabetic patients with AITD are known to show distinct clinical and immunological features from patients without AITD. This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to type 1 diabetes and AITD. The frequency of −1082G/A, −819C/T, and −592C/A polymorphisms was analyzed in 54 type 1 diabetic patients with AITD, 74 type 1 diabetic patients without AITD, 124 nondiabetic patients with AITD, and 107 healthy subjects in a case-control study. No significant differences on the allele and genotype frequencies of three polymorphisms were found not only in type 1 diabetic patients with AITD compared with normal controls, but also between nondiabetic patients with AITD and healthy controls. The distribution of IL-10 gene haplotypes was also similar between both patient groups and normal controls. These results suggest that IL-10 gene promoter region polymorphisms are not associated with genetic susceptibility to type 1 diabetes and AITD.
- Publication
Annals of the New York Academy of Sciences, 2003, Vol 1005, Issue 1, p344
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1288.055