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- Title
Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.
- Authors
Sakofsky, Cynthia J.; Saini, Natalie; Klimczak, Leszek J.; Chan, Kin; Malc, Ewa P.; Mieczkowski, Piotr A.; Burkholder, Adam B.; Fargo, David; Gordenin, Dmitry A.
- Abstract
Graph: Fig 4 Cluster types in gamma-exposed yeast.(A) Example of selected clusters overlapping with the triple reporter on chromosome 2 found in WT Can1-Red diploid or haploid gamma-exposed yeast. Four cluster types are illustrated: (I) C-coordinated or G-coordinated clusters, comprised exclusively of either mutated C's or mutated G's on the top strand; (II) C-coordinated clusters adjacent to a single G. The terminal G in these clusters may have originated from the same mutagenic event that formed the C-coordinated portion of the cluster or it could be an unlinked random, scattered mutation.
- Subjects
DNA repair; FIG; DNA mismatch repair; SPHERES
- Publication
PLoS Biology, 2020, Vol 18, Issue 3, p1
- ISSN
1544-9173
- Publication type
Correction Notice
- DOI
10.1371/journal.pbio.3000695