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- Title
The Effects of Propafenone on Postoperative Atrial Fibrillation in Adult Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials.
- Authors
Jin-He Deng; Jing Li; Fan-Rong He; Yun-Tai Yao
- Abstract
Background. Previous research has only conducted a restricted amount of investigations on the e5ectiveness of propafenone in preventing and treating of atrial 6brillation (AF) after cardiac surgery. Hence, a comprehensive evaluation and meta-analysis were performed to evaluate the e5ectiveness and safety of propafenone in individuals undergoing cardiac surgery for postoperative atrial 6brillation (POAF). Methods. A meta-analysis of randomized controlled trials was conducted. Until September 15th, 2023, various databases were searched. The main focal points consisted of the presence of POAF, transition from AF to sinus rhythm, and reappearance of AF. The odds ratios (ORs) for treatment e5ects on dichotomous variables were calculated. Results. The analysis of data included 9 controlled trials that were randomized and had 1014 patients. The findings indicated that propafenone has a signi6cant impact on reducing the occurrence of POAF in adult patients who undergo cardiac surgery (OR, 0.52; 95% CI: 0.30, 0.89; P = 0.02). In addition, it was observed that propafenone signi6cantly increase the rate of conversion to sinus rhythm from AF within 20 min (OR, 5.39; 95% CI: 2.25, 12.91; P = 0.0002) and 1 hour (OR, 2.89; 95% CI: 1.50, 5.57; P = 0.002) after administration. Surprisingly, the administration of propafenone treatment did not have a signi6cant impact on the rate of conversion to sinus rhythm from AF within 24 hours (OR, 0.63; 95% CI: 0.38, 1.04; P = 0.07) after administration. Conclusions. The present study suggests that the postoperative administration of propafenone to adult cardiac surgery patients is both safe and e5ective for preventing and treating POAF.
- Subjects
CARDIAC surgery; RANDOMIZED controlled trials; ATRIAL fibrillation; PROPAFENONE; CARDIAC patients
- Publication
Journal of Cardiac Surgery, 2024, Vol 2024, p1
- ISSN
0886-0440
- Publication type
Article
- DOI
10.1155/2024/5579727