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- Title
Frontispiece: An Integrated Imaging Probe Design: The Synthesis of <sup>99m</sup>Tc/Re-Containing Macrocyclic Peptide Scaffolds.
- Authors
Hickey, Jennifer L.; Simpson, Emily J.; Hou, Jinqiang; Luyt, Leonard G.
- Abstract
Metal Scaffolding With the proper design, cyclic peptides may act as scaffolds emulating β‐sheet regions, enabling investigation into molecular recognition and protein aggregation. In their Full Paper on page 568 ff., L. G. Luyt et al. report on the synthesis of peptide macrocycles, which have been stitched together through a pyridyl tridentate chelation core, followed by metal coordination using 99mTc or Re tricarbonyl. Structural analysis revealed that the peptide backbone exists in a similar conformation both before and after metal incorporation.
- Subjects
MACROCYCLIC compounds; PEPTIDES
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 2, pn/a
- ISSN
0947-6539
- Publication type
Other
- DOI
10.1002/chem.201580262