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- Title
The Plasma Haloperidol and Reduced Haloperidol Concentrations in Chinese Schizophrenic Patients: Relationship between Reduced Haloperidol/Haloperidol Ratio and Red Blood Cell Haloperidol Reductase Activity.
- Authors
Wong, B. Y. M.; Mo-Yin Chan, B. Y. M.; Wong, M. T. H.; Lieh-Mak, F.
- Abstract
Fifteen Chinese schizophrenic patients were given titrated doses of haloperidol (0.05-0.42 mg/kg) for two weeks. All these 15 patients were in clinical remission on maintenance dose of haloperidol. The mean plasma haloperidol and reduced haloperidol concentrations were 16.8 ± 4.8 ng/mI and 13.6 ± 5.7 ng/ml respectively. The plasma RHAL/HAL ratio was in the range of 013-l 94. These values were similar to that reported for the Japanese population. The frequency distribution appeared to be bimodal. RBC reductase activity were found to be distributed normally and no correlation was found between plasma RHAL/HAL ratio and RHC reductase activity.
- Subjects
ANTIPSYCHOTIC agents; SCHIZOPHRENIA; PSYCHOSES; REDUCTION of drug dosage; ERYTHROCYTES; BLOOD plasma
- Publication
Human Psychopharmacology: Clinical & Experimental, 1992, Vol 7, Issue 2, p123
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.470070207