We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities.
- Authors
Kiem, Phan Van; Yen, Duong Thi Hai; Hung, Nguyen Van; Nhiem, Nguyen Xuan; Tai, Bui Huu; Trang, Do Thi; Yen, Pham Hai; Ngoc, Tran Minh; Minh, Chau Van; Park, SeonJu; Lee, Jae Hyuk; Kim, Sun Yeou; Kim, Seung Hyun; Miceli, Natalizia
- Abstract
Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A–E (1–5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-D- glucopyranosyl-(1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their α-glucosidase and α-amylase inhibitory activities. Compounds 2–4 showed significant α-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 µM.
- Subjects
PREGNANE; GLUCOSIDASES; GLYCOSIDES; AYURVEDIC medicine; TRADITIONAL medicine; SAPONINS
- Publication
Molecules, 2020, Vol 25, Issue 11, p2525
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25112525