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- Title
Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus.
- Authors
Smetanina, Olga F.; Yurchenko, Anton N.; Girich (Ivanets), Elena V.; Trinh, Phan Thi Hoai; Antonov, Alexander S.; Dyshlovoy, Sergey A.; von Amsberg, Gunhild; Kim, Natalya Y.; Chingizova, Ekaterina A.; Pislyagin, Evgeny A.; Menchinskaya, Ekaterina S.; Yurchenko, Ekaterina A.; Van, Tran Thi Thanh; Afiyatullov, Shamil S.; Sakai, Ryuichi
- Abstract
Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.
- Subjects
MARINE fungi; ASPERGILLUS; PARKINSON'S disease
- Publication
Molecules, 2020, Vol 25, Issue 1, p61
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25010061