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- Title
Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra.
- Authors
de Carvalho Junior, Almir Ribeiro; Oliveira Ferreira, Rafaela; de Souza Passos, Michel; da Silva Boeno, Samyra Imad; Glória das Virgens, Lorena de Lima; Ventura, Thatiana Lopes Biá; Calixto, Sanderson Dias; Lassounskaia, Elena; de Carvalho, Mario Geraldo; Braz-Filho, Raimundo; Curcino Vieira, Ivo Jose; Guerrini, Alessandra
- Abstract
A phytochemical study of leaves and twigs of Psychotria nuda resulted in 19 compounds, including five indole alkaloids, N,N,N-trimethyltryptamine, lyaloside, strictosamide, strictosidine, and 5α-carboxystrictosidine; two flavonolignans, cinchonain Ia and cinchonain Ib; an iridoid, roseoside; a sugar, lawsofructose; a coumarin, scopoletin; a diterpene, phytol; three triterpenes, pomolic acid, spinosic acid, and rotungenic acid; and five steroids, sitosterol, stigmasterol, campesterol, β-sitosterol-3-O-β-d-glucoside, and β-stigmasterol-3-O-β-d-glucoside. Some compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis and their ability to inhibit NO production by macrophages stimulated by lipopolysaccharide (LPS). The compounds pomolic acid, spinosic acid, strictosidine, and 5α-carboxystrictosidine displayed antimycobacterial activity with minimum inhibitory concentrations ranging from 7.1 to 19.2 µg/mL. These compounds showed promising inhibitory activity against NO production (IC50 3.22 to 25.5 μg/mL). 5α-carboxystrictosidine did not show cytotoxicity against macrophages RAW264.7 up to a concentration of 100 µg/mL. With the exception of strictosamide, this is the first report of the occurrence of these substances in P. nuda.
- Subjects
MYCOBACTERIAL diseases; NITRIC oxide; TRITERPENES; ALKALOIDS; PSYCHOTRIA
- Publication
Molecules, 2019, Vol 24, Issue 6, p1026
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24061026