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- Title
Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver.
- Authors
Ji-Yeon Yu; Jae Yeo Ha; Kyung-Mi Kim; Young-Suk Jung; Jae-Chul Jung; Seikwan Oh
- Abstract
This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases.
- Subjects
ANTI-inflammatory agents; LICORICE (Plant); THERAPEUTIC use of plant extracts; LABORATORY mice; NITRIC oxide synthesis; CYCLOOXYGENASE 2; INTERLEUKIN-6; LIVER diseases
- Publication
Molecules, 2015, Vol 20, Issue 7, p13041
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules200713041