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- Title
Full-length genome sequence analysis of a Hungarian porcine reproductive and respiratory syndrome virus isolated from a pig with severe respiratory disease.
- Authors
Bálint, Ádám; Balka, Gyula; Horváth, Péter; Kecskeméti, Sándor; Dán, Ádám; Farsang, Attila; Szeredi, Levente; Bányai, Krisztián; Bartha, Dániel; Olasz, Ferenc; Belák, Sándor; Zádori, Zoltán
- Abstract
Here, we report the isolation of a type 1 porcine reproductive and respiratory syndrome virus (PRRSV) strain from a clinical outbreak of severe respiratory problems and high fever. Next-generation sequencing was used to determine the complete genome sequence of the isolate (9625/2012). The virus belongs to a new branch within subtype 1, clade D, and shows the highest similarity to PRRSV Olot/1991 and to the Amervac vaccine strain. Mutation analysis of 9625/2012 revealed no evidence of recombination but did show a high proportion of amino acid substitutions in the putative neutralizing epitopes, suggesting an important role of selective immune pressure in the evolution of PRRSV 9625/2012.
- Subjects
PORCINE reproductive &; respiratory syndrome; SWINE diseases; RESPIRATORY diseases; NUCLEOTIDE sequence; VIRAL vaccines; AMINO acid analysis
- Publication
Archives of Virology, 2015, Vol 160, Issue 2, p417
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-014-2265-2