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- Title
Beneficial Effects of Verapamil on Intestinal Ischemia and Reperfusion Injury: Pretreatment versus Postischemic Treatment.
- Authors
Kimura, M.; Kataoka, M.; Kuwabara, Y.; Sato, A.; Kato, T.; Narita, K.; Okahira, T.; Fujii, Y.
- Abstract
We studied the effect of verapamil on intestinal ischemia and reperfusion (I/R) injury. Intestinal ischemia was induced by clamping the superior mesenteric artery for 30 min followed by reperfusion. Magnetic resonance spectroscopy was employed as a marker of the changes in the energy metabolism. Further, histological changes and the changes of water contents were evaluated. Recovery rates of energy metabolism after intestinal I/R were improved by verapamil, administered before and after ischemia, and tissue edema was significantly reduced with verapamil. These findings suggest that verapamil results in an improved recovery of the energy metabolism and cellular preservation, presumably by reducing the intracellular calcium influx.
- Subjects
INTESTINAL ischemia; VERAPAMIL; REPERFUSION injury; PROTON magnetic resonance spectroscopy; CELL preservation
- Publication
European Surgical Research, 1998, Vol 30, Issue 3, p191
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000008576