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- Title
Analysis of the Morphology of Monocytes and Lymphocytes from COVID-19 Patients Using Low-Voltage Scanning Electronic Microscopy.
- Authors
Velmiskina, A. A.; Nikitin, Yu. V.; Mikhailovskii, V. Yu.; Mosenko, S. V.; Anisenkova, A. Yu.; Apalko, S. V.; Sushentseva, N. N.; Scherbak, S. G.; Ivanov, A. M.; Galaktionov, N. K.; Shneider, O. V.; Kondratov, K. A.
- Abstract
Severe course of COVID-19 is largely determined by hyperactivation of the immune system, or cytokine storm, in which immune cells (lymphocytes, monocytes, etc.) play a major role. Using low-voltage scanning electron microscopy, we studied the morphology of lymphocytes and monocytes during cytokine storm. Monocytes and lymphocytes were isolated by fluorescence sorting from the blood of healthy volunteers (n=6) and patients with COVID-19 (n=5) during cytokine storm (IL-6>23 ng/ml, smear positive for SARS-CoV-2). For each patient, 11-32 individual cells were analyzed at magnification of 18-32,000 times. Measurements showed that monocyte size was increased during cytokine storm (p=0.0001).
- Subjects
COVID-19; LYMPHOCYTES; CYTOKINE release syndrome; MORPHOLOGY; SCANNING electron microscopy; FETAL monitoring
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 176, Issue 2, p297
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-024-06011-4