We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Changes in the Neuronal Population of the Spinal Cord of Mice with Experimental Autoimmune Encephalomyelitis as a Model of Multiple Sclerosis.
- Authors
Balashov, A. V.; Pankov, V. G.; Balashov, V. P.; Shikhanov, N. P.; Gushchina, S. V.
- Abstract
We performed a quantitative study of the neuronal population in the spinal cord of mice with acute and chronic model of experimental autoimmune encephalomyelitis. Immunohistological/immunofluorescent analysis with motor neuron marker ChAT revealed a significant decrease in the number of motor neurons in the ventral horns of the lumbar spinal cord in the acute form of autoimmune encephalomyelitis, with the further appearance of large empty (containing no motor neurons) areas in the ventral horns in the chronic form. The development of experimental autoimmune encephalomyelitis is accompanied by degradation and death of neurons, in particular ChAT+ motor neurons.
- Subjects
SPINAL cord; MULTIPLE sclerosis; ENCEPHALOMYELITIS; MOTOR neurons; NEURON analysis; MYELIN proteins
- Publication
Bulletin of Experimental Biology & Medicine, 2022, Vol 173, Issue 5, p590
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-022-05593-1