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- Title
Research progress in biological role of TIGIT and its application in bladder cancer.
- Authors
ZHANG Yawei; SHI Hongjin; FU Shi; WANG Jiansong; WANG Haifeng
- Abstract
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a transmembrane glycoprotein expressed on the surface of immune cells. TIGIT expression is up-regulated in bladder cancer and will have an important impact on bladder cancer development and poor prognosis. Immunotherapy that blocks TIGIT signaling is expected to improve the prognosis of bladder cancer. With further research, TIGIT is likely to become a target for bladder cancer diagnosis and treatment. This article reviews the structure, immunomodulatory effect and the research progress of TIGIT in bladder cancer.
- Subjects
BLADDER cancer; CANCER diagnosis
- Publication
Journal of Practical Medicine / Shiyong Yixue Zazhi, 2024, Vol 40, Issue 12, p1762
- ISSN
1006-5725
- Publication type
Article
- DOI
10.3969/j.issn.1006-5725.2024.12.025