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- Title
Bioinhibition of human fibroblast cultures sensitized to Q-switch II dye and treated with the Nd:YAG laser: A new technique of photodynamic therapy with lasers.
- Authors
Castro, Dan J.; Ward, Paul H.; Saxton, Romaine E.; Fetterman, Harold R.; Castro, Donna J.
- Abstract
Kodak Q-switch II dye has recently proven to be nn effective biostimulative agent on normal human fibroblast cultures. The potential for this dye as a new chemosensitizing agent for the treatment of connective tissue diseases and wound healing with the Nd:YAG laser was examined. Two normal fibroblast cell lines were first sensitized to a nontoxic dose of Q-switch II dye, then subjected to treatment with an Nd:YAG laser at 1, 060 nm, with varying levels of energy and temperatures determined by a reproducible method of dosimetry. The results indicate that Q-switch II dye at nontoxic doses of 0.1 μg/ml enhances the cytotoxic effects of the Nd:YAG laser at temperatures as low as 36 °C. Furthermore, at physiological temperature ranges as low as 24 °C to 34 °C, cell duplication was inhibited, but cell viability was not affected. Similar results were not observed when fibroblast cultures were treated with the laser alone. These observations suggest that Q-switch II dye is an effective chemosensitizing agent for the Nd:YAG laser and could potentially be used to reduce collagen deposits in conditions such as keloids and hypertrophic scars.
- Publication
Laryngoscope, 1989, Vol 99, Issue 4, p421
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1288/00005537-198904000-00012