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- Title
Genomewide association studies for hematological traits and T lymphocyte subpopulations in a Duroc × Erhualian F<sub>2</sub> resource population.
- Authors
Zhang, J.; Chen, J. H.; Liu, X. D.; Wang, H. Y.; Liu, X. L.; Li, X. Y.; Wu, Z. F.; Zhu, M. J.; Zhao, S. H.
- Abstract
It has been shown that hematological traits can act as important indicators of immune function in both humans and livestock. T lymphocytes are key components of the adaptive immune system, playing a critical role in immune response. To identify genomic regions affecting hematological traits and T lymphocyte subpopulations, we performed both a SNP-based genomewide association study (GWAS) and a haplotype analysis for 20 hematological traits and 8 T cell subpopulations at 3 different time points (d 20, 33, and 35) in a Duroc × Erhualian F2 inter-cross population. Bonferroni correction was used to calculate the threshold P-values for suggestive and 5% genomewide significance levels. In total, for SNP-based GWAS, we detected 96 significant SNP, including 15 genomewide-significant SNP, associated with 23 hematological traits and 234 significant SNP, including 27 genomewide-significant SNP, associated with 8 T cell subpopulations. Meanwhile, we identified 563 significant SNP, including τ genomewide-significant SNP, associated with 5 hematological traits and 2,407 significant SNP, including 1,261 genomewide-significant SNP, associated with 8 T cell subpopulations by haplotype analysis. Among the significant regions detected, we propose both the NCK adaptor protein 2 (NCK2) gene and the four and a half LIM domains 2 (FHL2) gene on SSC3 as plausible candidate genes associated with CD8+/CD8- T lymphocytes at d 20. The findings provide insights into the basis of molecular mechanisms that are involved with immune response in the domestic pig and would aid further identification of causative mutations.
- Subjects
T cells; HEMATOLOGY; IMMUNE system; IMMUNE response; HAPLOTYPES; SINGLE nucleotide polymorphisms; SWINE
- Publication
Journal of Animal Science, 2016, Vol 94, Issue 12, p5028
- ISSN
0021-8812
- Publication type
Article
- DOI
10.2527/jas.2016-0924