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- Title
Gene Expression Profiling in Acute Stanford Type B Aortic Dissection.
- Authors
Wang, Lixin; Yao, Lei; Guo, Daqiao; Wang, Chunsheng; Wan, Bo; Ji, Guoqing; Yang, Cheng; Zhang, Jing; Sheng, Zaozhuo; Fu, Weiguo; Wang, Yuqi
- Abstract
Objective: To compare the gene expression profiles of the aorta specimens between patients with Stanford type B aortic dissection (AD) and controls. Materials and Methods: Samples of descending aorta were collected from patients with type B AD (n = 12) and from multiorgan donors as controls (n = 12). Phalanx whole genome microarray was used to analyze differential gene expression. Results: Of the 6375 probes validated, 623 genes were found to be differentially expressed between patients with type B AD and controls (fold change ≥2). Gene ontology analysis identified significantly enriched gene groups pertaining to cell–cell adhesion, extracellular matrix, cell–matrix adhesion, cytoskeleton, immune and inflammatory response, and apoptosis. Conclusion: Genes encoding components related to integrity and strength of the aortic wall were downregulated, whereas those related to inflammatory response were upregulated in type B AD. The altered patterns of gene expression indicate preexisting structural defects that are probably a consequence of insufficient remodeling of the aortic wall.
- Subjects
DIABETES complications; CARDIOVASCULAR disease diagnosis; AORTA; SMOKING; DNA; VASCULAR surgery; DEMOGRAPHY; GENE expression; GENES; AORTIC dissection; HYPERTENSION; INFORMED consent (Medical law); EVALUATION of medical care; MEDICAL emergencies; POLYMERASE chain reaction; T-test (Statistics); DATA analysis; CONTROL groups; MICROARRAY technology; DESCRIPTIVE statistics; DISEASE complications; SYMPTOMS; GENETICS; DIAGNOSIS; ANATOMY; DISEASE risk factors; PHYSIOLOGY
- Publication
Vascular & Endovascular Surgery, 2012, Vol 46, Issue 4, p300
- ISSN
1538-5744
- Publication type
Article
- DOI
10.1177/1538574412443315