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- Title
Possible Participation of Nitric Oxide/Cyclic Guanosine Monophosphate/Protein Kinase C/ATP-Sensitive K.
- Authors
Mohamad, Azam Shah; Akhtar, Muhammad Nadeem; Khalivulla, Shaik Ibrahim; Perimal, Enoch Kumar; Khalid, Mohamed Hanief; Ong, Hui Ming; Zareen, Seema; Akira, Ahmad; Israf, Daud Ahmad; Lajis, Nordin; Sulaiman, Mohd Roslan
- Abstract
The possible mechanisms of action in the antinociceptive activity induced by systemic administration (intraperitoneal, i.p.) of flavokawin B (FKB) were analysed using chemical models of nociception in mice. It was demonstrated that i.p. administration of FKB to the mice at 0.3, 1.0, 3.0 and 10 mg/kg produced significant dose-related reduction in the number of abdominal constrictions. The antinociception induced by FKB in the acetic acid test was significantly attenuated by i.p. pre-treatment of mice with arginine, the substrate for nitric oxide synthase or glibenclamide, the ATP-sensitive K channel inhibitor, but was enhanced by methylene blue, the non-specific guanylyl cyclase inhibitor. FKB also produced dose-dependent inhibition of licking response caused by intraplantar injection of phorbol 12-myristate 13-acetate, a protein kinase C activator (PKC). Together, these data indicate that the NO/cyclic guanosine monophosphate/PKC/ATP-sensitive K channel pathway possibly participated in the antinociceptive action induced by FKB.
- Subjects
NITRIC oxide; CYCLIC guanylic acid; PROTEIN kinases; ADENOSINE triphosphate; LABORATORY mice; PHORBOLS
- Publication
Basic & Clinical Pharmacology & Toxicology, 2011, Vol 108, Issue 6, p400
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2010.00670.x