We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Screening of Anorectal and Oropharyngeal Samples Fails to Detect Bacteriophages Infecting Neisseria gonorrhoeae.
- Authors
Laumen, Jolein Gyonne Elise; Abdellati, Saïd; Manoharan-Basil, Sheeba Santhini; Van Dijck, Christophe; Van den Bossche, Dorien; De Baetselier, Irith; de Block, Tessa; Malhotra-Kumar, Surbhi; Soentjes, Patrick; Pirnay, Jean-Paul; Kenyon, Chris; Merabishvili, Maia
- Abstract
There are real concerns that Neisseria gonorrhoeae may become untreatable in the near future due to the rapid emergence of antimicrobial resistance. Alternative therapies are thus urgently required. Bacteriophages active against N. gonorrhoeae could play an important role as an antibiotic-sparing therapy. To the best of our knowledge, no bacteriophages active against N. gonorrhoeae have ever been found. The aim of this study was to screen for bacteriophages able to lyse N. gonorrhoeae in oropharyngeal and anorectal swabs of 74 men who have sex with men attending a sexual health clinic in Antwerp, Belgium. We screened 210 swabs but were unable to identify an anti-gonococcal bacteriophage. This is the first report of a pilot screening that systematically searched for anti-gonococcal phages directly from clinical swabs. Further studies may consider screening for phages at other anatomical sites (e.g., stool samples, urine) or in environmental settings (e.g., toilet sewage water of sex clubs or sexually transmitted infection clinics) where N. gonorrhoeae can be found.
- Subjects
ANTWERP (Belgium); NEISSERIA gonorrhoeae; MEDICAL screening; BACTERIOPHAGES; SEXUALLY transmitted diseases; WATER sampling; DRUG resistance in microorganisms
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 2, p268
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11020268