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- Title
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics.
- Authors
Murugaiyan, Jayaseelan; Kumar, P. Anand; Rao, G. Srinivasa; Iskandar, Katia; Hawser, Stephen; Hays, John P.; Mohsen, Yara; Adukkadukkam, Saranya; Awuah, Wireko Andrew; Jose, Ruiz Alvarez Maria; Sylvia, Nanono; Nansubuga, Esther Patience; Tilocca, Bruno; Roncada, Paola; Roson-Calero, Natalia; Moreno-Morales, Javier; Amin, Rohul; Kumar, Ballamoole Krishna; Kumar, Abishek; Toufik, Abdul-Rahman
- Abstract
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPR-Cas system. These alternative strategies may have the potential to change the treatment of multi-drug-resistant pathogens in human clinical settings.
- Subjects
DRUG resistance in microorganisms; DRUG resistance in bacteria; DRUG delivery systems; CRISPRS
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 2, p200
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11020200