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- Title
Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes.
- Authors
Ji, Hongwei; Ebinger, Joseph E.; Kwan, Alan C.; Reue, Karen; Sullivan, Jennifer C.; Shyy, John; Cheng, Susan
- Abstract
OBJECTIVE: To investigate whether the sex disparities in type 2 diabetes–associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control. RESEARCH DESIGN AND METHODS: We analyzed intensive versus standard BP control in relation to incident CVD events in women and men with type 2 diabetes, based on their age of hypertension diagnosis. RESULTS: Among 3,792 adults with type 2 diabetes (49% women), multivariable-adjusted CVD risk was increased per decade earlier age at hypertension diagnosis (hazard ratio 1.11 [1.03–1.21], P = 0.006). Excess risk associated with early-diagnosed hypertension was attenuated in the presence of intensive versus standard antihypertensive therapy in women (P = 0.036) but not men (P = 0.76). CONCLUSIONS: Women with type 2 diabetes and early-onset hypertension may represent a higher-risk subpopulation that not only contributes to the excess in diabetes-related CVD risk for women but may benefit from intensive BP control.
- Subjects
TYPE 2 diabetes; CARDIOVASCULAR diseases; HYPERTENSION; CARDIOVASCULAR diseases risk factors; BLOOD pressure
- Publication
Diabetes Care, 2024, Vol 47, Issue 6, p1028
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc23-2275