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- Title
血清羧化不全骨钙素对绝经后女性骨质疏松症诊疗意 义的探讨.
- Authors
吴志浩; 黄凯华; 刘康; 肖毓宸; 潘行滔; 孙强
- Abstract
Objective To detect the levels of serum undercarboxylated osteocalcin (ucOC) in postmenopausal women,and to explore its influencing factors and its significance in the diagnosis and treatment of osteoporosis in postmenopausal women. Methods Totally 108 patients attending our hospital’s orthopedics clinic were recruited from July 2015 to December 2016. The experimental and control groups were set up according to bone mineral density (BMD) T-score and history of fracture. Age, height,weight,body mass index (BM I) and BMD were recorded,and peripheral blood samples were taken to test blood alkaline phosphatase (ALP), serum calcium,phosphorus and ucOC. Statistical analyses of these indicators were undertaken. Results The level of ucOC in patients with osteoporosis was significant higher than that of the control group (P<0.05). Serum ucOC level was one of the influencing factors for osteoporosis (OR = 2. 806,P<0.05). ② Serum ucOC level had a significant and negative correlation with lumber BMD (r = -0.395,P<0.05), but there was no significant correlation with hip BMD (r = -0.248,P>0.05). Conclusion In postmenopausal women,the change in serum ucOC levels closely associated with the occurrence of osteoporosis,and high serum ucOC level is a risk factor for osteoporosis. Furthermore,serum ucOC level could be used as a reference for the early prediction and screening of osteoporosis in postmenopausal women.
- Publication
Chinese Journal of Osteoporosis, 2017, Vol 23, Issue 12, p1587
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2017.12.010