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- Title
In Vivo Temporal Penetration of Mesenchymal Stem Cell-Derived Exosome Eye Drops Across Ocular Tissue.
- Authors
Moon Nian Lim; Qi Hao Looi; Benson Koh; Man Lung Chan, Alvin; Fakharuzi, Noor Atiqah; Fakiruddin, Kamal Shaik; Navaretnam, Gowrisankari; Esa, Ezalia; Jhi Biau Foo; Chee Wun How; Abdul Halim, Wan Haslina Wan; Che' Amat, Azlan; Muhammad, Numan; Khairuddin, Nurul Hayah
- Abstract
This study explores the potential application of extracellular vesicles (EVs) or exosomes derived from human mesenchymal stem cells (MSCs) in ophthalmology. Exosomes were isolated from MSCs' culture supernatant, and applied as eye drops to rabbits' eyes. Samples of aqueous (AH) and vitreous humour (VH) were collected at different time points for exosomes marker analysis. Our results showed that CD63 was detected in all AH and VH samples. Whereas, for CD9 and CD81, despite minimally expressed in control samples, showed varying expression in VH samples at different time points, indicating penetration and retention of exosomes in the eyes' structure.
- Subjects
EYE drops; EXTRACELLULAR vesicles; MESENCHYMAL stem cells; EXOSOMES; HUMAN stem cells
- Publication
Malaysian Journal of Medicine & Health Sciences, 2023, Vol 19, p25
- ISSN
1675-8544
- Publication type
Article