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- Title
Room Temperature, Metal-Free Arylation of Aliphatic Alcohols.
- Authors
Ghosh, Raju; Lindstedt, Erik; Jalalian, Nazli; Olofsson, Berit
- Abstract
Diaryliodonium salts are demonstrated as efficient arylating agents of aliphatic alcohols under metal-free conditions. The reaction proceeds at room temperature within 90 min to give alkyl aryl ethers in good to excellent yields. Aryl groups with electron-withdrawing substituents are transferred most efficiently, and unsymmetric iodonium salts give chemoselective arylations. The methodology has been applied to the formal synthesis of butoxycaine.
- Subjects
THERMISTORS; THERMOMETERS; ISOTHERMAL processes; ALCOHOLS (Chemical class); ORGANIC compounds
- Publication
ChemistryOpen, 2014, Vol 3, Issue 2, p54
- ISSN
2191-1363
- Publication type
Article
- DOI
10.1002/open.201402006