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- Title
A pulmonary metastatic model of murine melanoma assessed by magnetic resonance imaging.
- Authors
Numata, Takafumi; Kiryu, Shigeru; Maeda, Tatsuo; Egusa, Chizu; Tsuboi, Ryoji; Harada, Kazutoshi
- Abstract
Immune checkpoint inhibitors and kinase inhibitors have improved prognosis of malignant melanoma ( MM) patients. However, these therapies cannot completely overcome the metastasis of MM. Thus, development of new therapy against metastasis should be required. A first step towards this goal, the aim of this study, is to establish a model of pulmonary metastasis from primary cutaneous MM and a monitoring system. B16-F10, a murine melanoma cell line, was subcutaneously injected into the pinna of mice. The pinna was excised when the lesion was detected. A metastatic nodule on T2-weighted imaging was detected 4 weeks after resection of the pinna. Lung metastases were observed in 37.5% (6/16) of the specimens. We established a novel murine model of the high pulmonary metastasis of MM. The MRI was useful for observations of the growth of the metastatic lesions in the lungs without dissection.
- Subjects
NEUROENDOCRINE tumors; METASTASIS; PULMONOLOGY; LUNGS; LUNG diseases
- Publication
Experimental Dermatology, 2017, Vol 26, Issue 7, p619
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.13327