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- Title
Gonadotropin Therapy versus Laparoscopic Ovarian Drilling in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients: A Retrospective Cost-Effectiveness Analysis.
- Authors
De Frène, Veerle; Gerris, Jan; Weyers, Steven; Dhont, Marc; Vansteelandt, Stijn; annemans, Lieven; De Sutter, Petra
- Abstract
<bold>Background: </bold>Gonadotropin therapy and laparoscopic ovarian drilling (LOD) are treatment options for ovulation induction (OI) in clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS) patients. The current evidence of the cost-effectiveness of both treatments is scarce, conflicting and performed from different health-economic perspectives.<bold>Methods: </bold>A retrospective health-economic evaluation was performed from a societal perspective in which human menopausal gonadotropin (hMG) therapy (n = 43) was compared with LOD (n = 35), followed by OI with CC and/or hMG if spontaneous ovulation did not occur within 2 months. Data were collected until the patients were pregnant, with a time limit of 6 months after the onset of treatment. Outcomes were expressed as ongoing pregnancy rate and number of live-born children.<bold>Results: </bold>The ongoing pregnancy rate was 21/35 (60%) after LOD and 30/43 (69.8%) after hMG treatment (relative risk 0.85, 95% CI 0.61-1.19). The societal cost per patient, up to an ongoing pregnancy, was significantly higher after LOD versus hMG treatment (adjusted mean difference EUR 1,073, 95% CI 180-1,967).<bold>Conclusion: </bold>This economic evaluation based on real-life data shows that the societal cost up to an ongoing pregnancy is less after hMG treatment when compared with LOD surgery in CC-resistant PCOS patients.
- Subjects
GONADOTROPIN; LAPAROSCOPIC surgery; CLOMIPHENE; MEDICAL economics; RETROSPECTIVE studies; MENOPAUSE; THERAPEUTICS
- Publication
Gynecologic & Obstetric Investigation, 2015, Vol 80, Issue 3, p164
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000373888